This is a list of differences between The Death Cure novel and the 2018 film adaptation.
- Book: They all in the custody of WICKED and Thomas, Newt, and Minho break free with the help of Brenda and Jorge.
- Movie: Thomas and his friends start off apart from WCKD, but WCKD has captured most of their friends, including Minho.
- Movie: Teresa died when WCKD collapsed. In the book, she was crushed to death by a huge block of stone.
- Book: Newt dies by forcing Thomas to shoot him right on his forehead to prevent from going through the Gone and ends his "misery"
- Movie: Newt dies by stabbing himself with a blade to prevent the full transformation of a Crank.
- Book: WICKED failed to find a cure for The Flare
- Movie: WCKD succeeded in finding a cure for The Flare